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Anabolic steroids and athletes
Athletes who use oral anabolic steroids nearly always show depressed HDL levels as the buildup of 17-alpha alkylated oral anabolic steroids in the liver leads to a type of toxic or chemical hepatitis. Hormone-dependent disorders have also been associated with the use of steroids and the production of hepatic encephalopathy. However, the association with CEN is less clear, largely due to the lack of a controlled study to compare the use of oral anabolic steroids with the use of other anti-androgenic drugs (ADs), anabolic steroids and anesthesia. Since the use of oral anabolic steroids is more common in athletes than with other doping methods, it is possible that the association with CEN is due to a more prevalent form of adverse reaction to or withdrawal from oral anabolic steroids in athletes and may account for the decreased incidence of CEN in these athletes. In sum, the association between oral anabolic steroid use and CEN is unclear, anabolic steroids and birth control pills.
Paediatric athletes who use oral anabolic steroids have higher risk of CEN compared to those who take oral anabolic steroids with other anti-androgenic drugs. Paediatric athletes who are using oral anabolic steroids have a higher incidence of CEN than those who take oral anabolic steroids with other anti-androgenic drugs or those who take oral anabolic steroids with ADs.
There is a positive relation between the use of CEN to children and the risk of other severe conditions such as cancer in children and the increased risk of cancer in adults, anabolic steroids and birth control.
A number of studies support the association between CEN and other CVD risk factors, anabolic steroids and anesthesia. Oral androgens increase the risk of CVD (1–4, 8, 9). It is likely, therefore, that oral androgen receptors stimulate the development of CVD and that CVD increases the risk of the occurrence and progression of CEN.
A number of clinical groups report a positive association between the use of oral anabolic steroids and CEN. An association between CEN and any of some other CVD risk factors has been reported in a number of clinical samples. In the present meta-analysis, we investigated the association between CEN and CVD risk factors and the use of oral androgenic steroids, anabolic steroids and bipolar disorder.
The Cochrane Central Register of Controlled Trials was searched by hand for all systematic reviews of clinical trials, articles and case studies published in English from 1969 to January 2013, and using a modified version of the search strategy (Table 1), anabolic steroids and acute kidney injury. For additional information about the search strategy and results of the review, see Cochrane Central Register of Controlled Trials: search strategy and results, anabolic steroids and corticosteroids.
Table 1: search strategy
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